KRAS G12C inhibitor 43

Names

[ CAS No. ]:
2648808-69-7

[ Name ]:
KRAS G12C inhibitor 43

Biological Activity

[Description]:

KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells ,respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C


[References]

[1]. Xu Wei, et al. Pyridopyrimidine kras g12c mutant protein inhibitor. WO2021139678A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H35N7O3

[ Molecular Weight ]:
577.68

Related Compounds