TREM2 agonist-1

Names

[ CAS No. ]:
2738486-70-7

[ Name ]:
TREM2 agonist-1

Biological Activity

[Description]:

TREM2 agonist-1 (I-246) is a triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50 between 3.0 μM and 100 μM)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

TREM2 agonist-1 (0-100 μM; 16 h) treatment activates hTREM2 in HEK293 cell[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0-100 μM Incubation Time: 16 hours Result: Showed an EC50 value between 3.0 μM and 100 μM.

[References]

[1]. Lara C. CZABANIUK, et al. Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use. WO2021226629A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H21ClFN5O

[ Molecular Weight ]:
437.90

Related Compounds