Thalidomide-5-PEG4-NH2 hydrochloride
Names
[ CAS No. ]:
2743434-24-2
[ Name ]:
Thalidomide-5-PEG4-NH2 hydrochloride
Biological Activity
[Description]:
Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[Related Catalog]:
[Target]
Cereblon
[In Vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H28ClN3O8
[ Molecular Weight ]:
485.92