7-Ethoxyresorufin-d5

Names

[ CAS No. ]:
2749329-28-8

[ Name ]:
7-Ethoxyresorufin-d5

Biological Activity

[Description]:

7-Ethoxyresorufin-d5 is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Others
Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118(1):57-62.

[3]. Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H6D5NO3

[ Molecular Weight ]:
246.27

Related Compounds