VPC-13789

Names

[ CAS No. ]:
2761146-51-2

[ Name ]:
VPC-13789

Biological Activity

[Description]:

VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC50=0.19 μM)[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Signaling Pathways >> Others >> Androgen Receptor

[References]

[1]. Eric Leblanc , et al. Development of 2-(5,6,7-Trifluoro-1 H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2021 Oct 28;64(20):14968-14982.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H16F3N3O

[ Molecular Weight ]:
383.37

Related Compounds