Anti-osteoporosis agent-1

Names

[ CAS No. ]:
2761577-50-6

[ Name ]:
Anti-osteoporosis agent-1

Biological Activity

[Description]:

Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC50=18 µM) [1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Inflammation/Immunology

[In Vitro]

Anti-osteoporosis agent-1 is an active molecule which showed effective mineralisation of osteoblast cells and up regulates the osteogenic marker gene such as Bmp-2, Runx-2 and Type-1col at both transcriptional and translational level. Besides exhibiting potential osteogenic activity. In addition, Anti-osteoporosis agent-1 also own significant anti-apoptotic activity at 1 pM &100 pM concentration and increases the osteoblast survival in serum deprived conditions[1].

[References]

[1]. Kriti Sharma, et al. Pyrazoline analogues: Design, synthesis, and evaluation of anti-osteoporosis activity. Bioorg Med Chem Lett. 2022 Mar 15; 60:128585.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H19ClN2O2

[ Molecular Weight ]:
354.83

Related Compounds