HIV-1 inhibitor-55

Names

[ CAS No. ]:
2771211-73-3

[ Name ]:
HIV-1 inhibitor-55

Biological Activity

[Description]:

HIV-1 inhibitor-55 (compound 4d) inhibits WT HIV-1 with an EC50 value of 8.6 nM. HIV-1 inhibitor-55 also shows inhibitory potency against single and double HIV-1 mutants. HIV-1 inhibitor-55 can be used for the research of virus infection[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[In Vitro]

HIV-1 inhibitor-55 对野生型 HIV-1 表现出抑制作用，EC50 值为 8.6 nM[1]。 HIV-1 inhibitor-55 对 HIV-1 突变体 L100I，K103N，Y181C，Y188L，E138K 和 F227L + V106A 表现出较强的抗逆转录酶活性，其 EC50 值分别为 1.1、0.12、0.36、0.75、0.033 和 3.06 μM[1]。 HIV-1 inhibitor-55 抑制野生型 HIV-1 逆转录的活性，IC50 值为 0.11 μM[1]。

[References]

[1]. Ming W, et al. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. Eur J Med Chem. 2023 Feb 15;248:115114.  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H32N6O4S

[ Molecular Weight ]:
548.66

Related Compounds