ALK5-IN-28

Names

[ CAS No. ]:
2785430-84-2

[ Name ]:
ALK5-IN-28

Biological Activity

[Description]:

ALK5-IN-28 (compound Ex-05) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-28 has the potential to inhibit growth of tumour in vivo. ALK5-IN-28 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad

[Target]

ALK5:≤10 nM (IC50)


[References]

[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H27N7

[ Molecular Weight ]:
425.53

Related Compounds