ALK5-IN-29

Names

[ CAS No. ]:
2785430-85-3

[ Name ]:
ALK5-IN-29

Biological Activity

[Description]:

ALK5-IN-29 is an selective activin receptor-like kinase (ALK) inhibitor. ALK5-IN-29 can inhibit the activity of ALK5 with an IC50 value of ≤10 nM. ALK5-IN-29 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[Target]

IC50: ≤10 nM (ALK5/2); ≤100 nM (RD-SMAD receptor)[1]


[In Vitro]

ALK5-IN-29 (EX-06) has kinase inhibition of ALK5 with an IC50 value of ≤10 nM[1]. ALK5-IN-29 has kinase selectivity of ALK2/ALK5 with an IC50 value of ≤10 nM[1]. ALK5-IN-29 shows TGFB-RI inhibition (RD-SMAD receptor activity) with an IC50 value of ≤100 nM[1].

[References]

[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent. WO2022126133A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25FN8

[ Molecular Weight ]:
444.51

Related Compounds