p-Hydroxybenzaldehyde-d5

Names

[ CAS No. ]:
298704-22-0

[ Name ]:
p-Hydroxybenzaldehyde-d5

[Synonym ]:
4-hydroxy-2,3,5,6-d4-benz(aldehyde-d1)
4-Hydroxybenzaldehyde-Alpha,2,3,5,6-d5
2,3,5,6-d4-4-hydroxy-benzaldehyde-d1

Biological Activity

[Description]:

p-Hydroxybenzaldehyde-d5 is the deuterium labeled p-Hydroxybenzaldehyde[1]. p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Zhang J, et al. The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor. Malays J Med Sci. 2017 Mar;24(2):94-99.  

Chemical & Physical Properties

[ Molecular Formula ]:
C7HD5O2

[ Molecular Weight ]:
127.15200

[ Exact Mass ]:
127.06800

[ PSA ]:
37.30000

[ LogP ]:
1.20470

Related Compounds