(+)-Sotalol

Names

[ Name ]:
(+)-Sotalol

[Synonym ]:
Sotolol
Betacotdone
d,l-sotalol
SORBITOL

Biological Activity

[Description]:

(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[Target]

β-adrenoceptor

[In Vitro]

(+)-Sotalol (1, 10, 100 µM) 在离体心肌中增加动作电位持续时间[2]。 (+)-Sotalol (100 μM，60 分钟) 可延长三种细胞类型 (心内膜、心外膜、心肌中部和透壁细胞) 的动作电位[4]。

[In Vivo]

(+)-Sotalol (8 mg/kg，静脉注射) 抑制程序刺激诱导的犬室性心动过速[3]。 Animal Model: Programmed stimulated Dogs[3] Dosage: 8 mg/kg Administration: Intravenous injection (i.v.) Result: Increased normal zone ventricular refractoriness, and prevented propagation of programmed ventricular extra-stimuli of sufficient prematurity to elicit tachyarrhythmias.

[References]

[1]. ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727

[2]. Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan;7(1):116-25.

[3]. Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1132-41.

[4]. Serge Sicouri, et al. d-Sotalol Induces Marked Action Potential Prolongation and Early Afterdepolarizations in M but Not Epicardial or Endocardial Cells of the Canine Ventricle. Journal of Cardiovascular Pharmacology and Therapeuticshttps. 2016.