Androgen receptor antagonist 4

Names

[ CAS No. ]:
354815-43-3

[ Name ]:
Androgen receptor antagonist 4

Biological Activity

[Description]:

Androgen receptor antagonist 4 (Compound AT2) is an androgen receptor (AR) antagonist with an IC50 of 0.15 μM. Androgen receptor antagonist 4 efficiently antagonizes AR transcriptional activity, suppresses downstream target gene of AR, and blocks the DHT-induced AR nuclear translocation. Androgen receptor antagonist 4 shows anticancer activities[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Androgen Receptor

[Target]

IC50: 0.15 μM (Androgen receptor)[1]


[References]

[1]. Tang Q, et al. Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2020 Apr 15;192:112156.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H18ClN

[ Molecular Weight ]:
331.84

Related Compounds