JTC-017

Names

[ CAS No. ]:
357330-77-9

[ Name ]:
JTC-017

[Synonym ]:
Benzamide,3,5-dichloro-N-(5-((diethylamino)sulfonyl)-3-(dimethylamino)-2-methoxyphenyl)-4-hydroxy
JTC-017
UNII-7F4TZ7XGMO

Biological Activity

[Description]:

JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CRFR
Research Areas >> Metabolic Disease

[References]

[1]. Saito K, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005;129(5):1533-1543.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H25Cl2N3O5S

[ Molecular Weight ]:
490.40100

[ Exact Mass ]:
489.08900

[ PSA ]:
111.05000

[ LogP ]:
5.52120