BILR 355

Names

[ CAS No. ]:
380378-81-4

[ Name ]:
BILR 355

[Synonym ]:
5-ethyl-10-methyl-2-[2-(1-oxyquinolin-4-yloxy)ethyl]-5,10-dihydro-4,5,6,10-tetraazadibenzo[a,d]cyclohepten-11-one
BILR 355 BS
6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one,11-ethyl-5,11-dihydro-5-methyl-8-[2-[(1-oxido-4-quinolinyl)oxy]ethyl]
DIP007
6H-Dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one,11-ethyl-5,11-dihydro-5-methyl-8-[2-[(1-oxido-4-quinolinyl)oxy]ethyl]
5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one HCl
5,11-dihydro-11-ethyl-5-methyl-8-{2-{(4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2',3'-e]10 [1,4]diazepin-6-one HCl
5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Biological Activity

[Description]:

BILR 355 is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). BILR 355 is highly specific toward HIV-1 reverse transcriptase (RT). BILR 355 can be used for HIV infections research[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[References]

[1]. Fenglei Huang, et al. Pharmacokinetic and safety evaluation of BILR 355, a second-generation nonnucleoside reverse transcriptase inhibitor, in healthy volunteers. Antimicrob Agents Chemother. 2008 Dec;52(12):4300-7.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H23N5O3

[ Molecular Weight ]:
441.48200

[ Exact Mass ]:
441.18000

[ PSA ]:
87.40000

[ LogP ]:
4.06850

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream