pUL89 Endonuclease-IN-2

Names

[ CAS No. ]:
519021-48-8

[ Name ]:
pUL89 Endonuclease-IN-2

Biological Activity

[Description]:

pUL89 Endonuclease-IN-2 (Compound 15k) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 of 3.0 μM. Antiviral activities[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> CMV

[In Vitro]

Cell Viability Assay Cell Line: HFF cells Concentration: 10 μM Incubation Time: 168 hours Result: Inhibited HCMV replication in HFF cell with the EC50 value of 14.4 μM.

[References]

[1]. Tianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65(7):5830-5849.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H12F3N3O3S

[ Molecular Weight ]:
395.36

Related Compounds