Cephalexin (lysine)

Names

[ CAS No. ]:
53950-14-4

[ Name ]:
Cephalexin (lysine)

Biological Activity

[Description]:

Cephalexin (Cefalexin) lysine is a derivative of Cephalexin with lysine. Cephalexin is a potent, orally active and the first-generation cephalosporin antibiotic. Cephalexin kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacteria[1]


[In Vitro]

Cefalexin is not effective against infections caused by methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus, or Pseudomonas. Cefalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity[1].

[References]

[1]. Cefalexin

[2]. Aseel Mahmood Jawad, et al. Innovation, Preparation of Cephalexin Drug Derivatives and Studying of (Toxicity & Resistance of Infection). March 2020 International Journal of Psychosocial Rehabilitation 24(4):3754.

[3]. Hongbaek Cho, et al. Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell. . 2014 Dec 4;159(6):1300-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H31N5O6S

[ Molecular Weight ]:
493.58

Related Compounds