Maleic anhydride-1,4-13C2

Names

[ CAS No. ]:
67519-25-9

[ Name ]:
Maleic anhydride-1,4-13C2

[Synonym ]:
Maleic anhydride-1,4-13C2
<1,4-13C2>succinic anhydride
Succinic anhydride-1,4-13C2
1,4-<13C>-Bernsteinsaeureanhydrid

Biological Activity

[Description]:

Succinic anhydride-13C2 is the 13C labeled Succinic anhydride[1]. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C4H4O3

[ Molecular Weight ]:
102.05800

[ Exact Mass ]:
102.02300

[ PSA ]:
43.37000

[ Index of Refraction ]:
1.470

MSDS

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Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds