Dichlorphenamide disodium

Dichlorphenamide disodium is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research[1].

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

Research Areas >> Neurological Disease

Dichlorphenamide disodium can reduce IOP locally in male albino rabbits[1]. Animal Model: Male albino rabbits (approximately 2.5 kg)[1] Dosage: 50 μL 10% aqueous solutions of dichlorphenamide sodium or 2 mg/kg, 6 mg/kg Administration: Eye drop of 50 μL or Oral gavage of 2 mg/kg or 6 mg/kg，5 hours Result: Showed significant decrease in IOP at 30 min by instilling into eyes and decrease in IOP only at 1 h by orally after drug administration. And demonstrated that drug levels were significantly higher in the iris ciliary body and lower in the serum by instilling compared to oral administration.

[1]. V J Lotti, et al. Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits. Graefes Arch Clin Exp Ophthalmol. 1984;222(1):13-9. doi: 10.1007/BF02133771.