Acipimox sodium

Names

[ CAS No. ]:
76958-97-9

[ Name ]:
Acipimox sodium

Biological Activity

[Description]:

Acipimox (K-9321) sodium, a nicotinic acid analogue, is an antilipolytic compound. Acipimox sodium stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Acipimox sodium (0-100 µM; 0-4 hours) enhances leptin release from adipocytes isolated from Sprague-Dawley rats in a time- and dose- dependent manner[2]. Acipimox sodium (10 mM) stimulats leptin release in adipocytes from Streptozotocin (STZ)-treated and Zucker diabetic fat (ZDF) rats[2].

[In Vivo]

Acipimox sodium (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice[3]. Animal Model: Acipimox sodium (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice[3]. Dosage: 50 mg/kg Administration: Intraperitoneal injection Result: Reduced circulating levels of FFA and glucose after 3 h.

[References]

[1]. Vestergaard ET, et, al. Short-term acipimox treatment is associated with decreased cardiac parasympathetic modulation. Br J Clin Pharmacol. 2017 Dec;83(12):2671-2677.

[2]. Wang-Fisher YL, et, al. Acipimox stimulates leptin production from isolated rat adipocytes. J Endocrinol. 2002 Aug;174(2):267-72.

[3]. Ahrén B. Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed mice. Acta Physiol Scand. 2001 Feb;171(2):161-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C6H5N2NaO3

[ Molecular Weight ]:
176.11

Related Compounds