Garcinone B

Names

[ CAS No. ]:
76996-28-6

[ Name ]:
Garcinone B

[Synonym ]:
garcinone B
5,9,11-Trihydroxy-3,3-dimethyl-10-(3-methyl-but-2-enyl)-3H-pyrano[3,2-a]xanthen-12-one

Biological Activity

[Description]:

Garcinone B, a xanthone derivative, is a nature product that could be isolated from the pericarp of Mangosteen. Garcinone B is a potent ACE2 and Mpro inhibitor. Garcinone B can be used in research of COVID-19[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Suhandi C, et, al. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: A Computational Study. Molecules. 2023 Jul 4;28(13):5187.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H22O6

[ Molecular Weight ]:
394.42

[ Exact Mass ]:
394.14200

[ PSA ]:
100.13000

[ LogP ]:
4.75590

Related Compounds