Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2].

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0.1 pM-1 μM; 48 h) stimulates tyrosinase activity in a dose-dependent manner in Cloudman S91 mouse melanoma cells[1].

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0-50 pM; i.c.v.; single dose) exerts thermoregulatory effect in rats model[2]. Animal Model: Rat model[2] Dosage: 0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μL sterile saline Administration: Intracerebroventricular injection in the anterior hypothalamic-preoptic area (AHPOA) of rats; single dose; recorded 0, 10, 20, 30, 40, 50, and 60 min after injection Result: Showed greater difference than mean temperatures of animals receiving sterile saline group.

[1]. Marwan MM, et al. Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins. Mol Cell Endocrinol. 1985 Jul;41(2-3):171-7.

[2]. Lyn H, et al. α-Melanocyte-stimulating hormone (MSH) and [Nle4, D-Phe7]-α-MSH: Effects on core temperature in rats. Pharmacology Biochemistry and Behavior. 1993;44(3):533-538.