FFA3 agonist 1

Names

[ CAS No. ]:
886358-51-6

[ Name ]:
FFA3 agonist 1

Biological Activity

[Description]:

FFA3 agonist 1 (Compound 24) is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> GPR40
Research Areas >> Metabolic Disease

[In Vitro]

FFA3 agonist 1 增加诱导表达增强黄色荧光蛋白 (eYFP) 人游离脂肪酸受体 3 (hFFA3) 的 Flp-in-T-REx 293细胞中的 [35S]GTPgS 的掺入和 pERK1/2 的产生，减少中 cAMP 的产生[2]。 FFA3 agonist 1 增加人游离脂肪酸受体 3、鼠游离脂肪酸受体 3 (mFFA3)、兔游离脂肪酸受体 3 (rFFA3) 中 [35S]GTPgS 的掺入[2]。

[References]

[1]. Ulven ER, et al. Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators. J Med Chem. 2020 Apr 9;63(7):3577-3595.  

[2]. Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 Aug;86(2):200-10.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H22N2O3

[ Molecular Weight ]:
362.42

Related Compounds