Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt

Names

[ Name ]:
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt

[Synonym ]:
L-Alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-N-[(2S,3R)-2-{acetyl[(2S)-1-carboxy-3-oxo-2-pr ;opanyl]amino}-3-hydroxybutanoyl]-L-α-glutamine
L-α-Glutamine, L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-N-[(2S,3R)-2-[acetyl[(1S)-2 -carboxy-1-formylethyl]amino]-3-hydroxy-1-oxobutyl]-

Biological Activity

[Description]:

Caspase-8-IN-1 is a potent caspase-8 inhibitor[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Apoptosis >> Caspase

[Target]

Caspase-8

[References]

[1]. Joshi SG, et al. Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity. Infect Immun. 2003 Jul;71(7):4127-36.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1925.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉₅H₁₆₂N₂₀O₂₆

[ Molecular Weight ]:
2000.421

[ Flash Point ]:
1118.0±34.3 °C

[ Exact Mass ]:
1999.196899

[ LogP ]:
7.38

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.531