MK-4965

Names

[ CAS No. ]:
920035-77-4

[ Name ]:
MK-4965

Biological Activity

[Description]:

MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)[1]

[References]

[1]. Lai MT, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₃Cl₂N₅O₂

[ Molecular Weight ]:
426.26

[ Exact Mass ]:
425.04500

[ PSA ]:
110.57000

[ LogP ]:
5.01998