MK-0952

Names

[ CAS No. ]:
934995-87-6

[ Name ]:
MK-0952

Biological Activity

[Description]:

MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Neurological Disease

[Target]

PDE4:0.53 nM (IC50)


[In Vivo]

MK-0952 (10 mg/kg) induces malaise in the rat[1].

[References]

[1]. Michel Gallant, et al. Discovery of MK-0952, a Selective PDE4 Inhibitor for the Treatment of Long-Term Memory Loss and Mild Cognitive Impairment. Epub 2010 Sep 21.

[2]. Tingting Pan, et al. Dual Functional Cholinesterase and PDE4D Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis and Evaluation of tacrine-pyrazolo[3,4-b]pyridine Hybrids. Behav Brain Res. 2016 Apr 15;303:26-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H22FN3O4

[ Molecular Weight ]:
483.49000

[ Exact Mass ]:
483.15900

[ PSA ]:
104.78000

[ LogP ]:
4.84690

Related Compounds