TPNA10168

Names

[ Name ]:
TPNA10168

[Synonym ]:
1-chloro-3-(methylsulfinyl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one

Biological Activity

[Description]:

TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Inflammation/Immunology

[References]

[1]. Izumi Y, et al. TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway. J Pharmacol Sci. 2022 May;149(1):1-10.

Chemical & Physical Properties

[ Density]:
1.54±0.1 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
490.3±45.0 °C (760 mmHg)

[ Molecular Formula ]:
C₉H₉ClO₂S₂

[ Molecular Weight ]:
248.75

[ Exact Mass ]:
247.97300

[ PSA ]:
81.59000

[ LogP ]:
3.52360