Vandetanib(ZD6474)
Names
[ CAS No. ]:
443913-73-3
[ Name ]:
Vandetanib(ZD6474)
[Synonym ]:
Vandetanib
4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
ZACTIMA
ZD 6474
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
Caprelsa
ZD6474
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Vandetanib for research
Biological Activity
[Description]:
[Related Catalog]:
[Target]
VEGFR2:40 nM (IC50)
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
538.2±50.0 °C at 760 mmHg
[ Melting Point ]:
240-243ºC
[ Molecular Formula ]:
C22H24BrFN4O2
[ Molecular Weight ]:
475.354
[ Flash Point ]:
279.3±30.1 °C
[ Exact Mass ]:
474.106659
[ PSA ]:
59.51000
[ LogP ]:
5.51
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.629
[ Storage condition ]:
-20?C Freezer
Safety Information
[ Hazard Codes ]:
Xi
[ Safety Phrases ]:
24/25
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%