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Gingerenone A

Names

[ CAS No. ]:
128700-97-0

[ Name ]:
Gingerenone A

[Synonym ]:
(E)-gingerenone A
(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one
Y7369
gingerenone-A
1,7-bis(4-hydroxy-3-methoxyphenyl)-hept-4-en-3-one

Biological Activity

[Description]:

Gingerenone A is a Nrf2-Gpx4 activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale[1][2].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology

[Target]

Nrf2-Gpx4[1]


[References]

[1]. Yu TJ, et al. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Antioxidants (Basel). 2022 Mar 19;11(3):587.  

[2]. Chen Y, et al. Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway. J Agric Food Chem. 2022 Oct 5;70(39):12525-12534.  

Chemical & Physical Properties

[ Density]:
1.183g/cm3

[ Boiling Point ]:
571.3ºC at 760mmHg

[ Molecular Formula ]:
C21H24O5

[ Molecular Weight ]:
356.41

[ Flash Point ]:
200.3ºC

[ Exact Mass ]:
356.16200

[ PSA ]:
75.99000

[ LogP ]:
3.80570

[ Vapour Pressure ]:
1.19E-13mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
2-8 °C

Related Compounds