Kaempferol
Names
[ CAS No. ]:
520-18-3
[ Name ]:
Kaempferol
[Synonym ]:
3,4',5,7-Tetrahydroxyflavone Hydrate
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2- (4-hydroxyphenyl)-
Pelargidenolon
EINECS 208-287-6
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-
campherol
3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
KaeMpferol Hydrate
MFCD00016938
Swartziol
asurone
3,5,7,4'-tetrahydroxyflavone
nimbecetin
Trifolitin
Populnetin
3 4' 5 7-tetrahydroxyflavone
5,7,4'-trihydroxyflavonol
kampherol
Kaempferol
Rhamnolutin
Robigenin
Swartsiol
Rhamnolutein
3,4',5,7-tetrahydroxyflavone
3,4,5,7-Tetrahydroxyflavone
kempferol
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Estrogen receptor[1]
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.7±0.1 g/cm3
[ Boiling Point ]:
582.1±50.0 °C at 760 mmHg
[ Melting Point ]:
276°C
[ Molecular Formula ]:
C15H10O6
[ Molecular Weight ]:
286.236
[ Flash Point ]:
226.1±23.6 °C
[ Exact Mass ]:
286.047729
[ PSA ]:
111.13000
[ LogP ]:
2.05
[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C
[ Index of Refraction ]:
1.785
[ Storage condition ]:
−20°C
[ Water Solubility ]:
ethanol: 20 mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LK9275200
- CHEMICAL NAME :
- Flavone, 3,4',5,7-tetrahydroxy-
- CAS REGISTRY NUMBER :
- 520-18-3
- BEILSTEIN REFERENCE NO. :
- 0304401
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C15-H10-O6
- MOLECULAR WEIGHT :
- 286.25
- WISWESSER LINE NOTATION :
- T66 BO EVJ CR DQ& DQ GQ IQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 25 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,45,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,171,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,171,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H341
[ Precautionary Statements ]:
P281-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ WGK Germany ]:
-
[ RTECS ]:
LK9275200
[ HS Code ]:
2914501900
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914501900
[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
PLoS ONE 10(3) , e0121610, (2015)
Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic conc...
Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts.Biochem. Pharmacol. 96 , 337-48, (2015)
During senescence, cells express molecules called senescence-associated secretory phenotype (SASP), including growth factors, proinflammatory cytokines, chemokines, and proteases. The SASP induces a c...
Kaempferol-3-O-rutinoside from Afgekia mahidoliae promotes keratinocyte migration through FAK and Rac1 activation.J. Nat. Med. 69 , 340-8, (2015)
The restoration of the epidermal epithelium through re-epithelialization is a critical process in wound healing. Directed keratinocyte migration to the wound is required, and the retardation of this p...