Silymarin
Names
[ CAS No. ]:
22888-70-6
[ Name ]:
Silymarin
[Synonym ]:
flavobin
(2R,3R)-3,5,7-Trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
EINECS 245-302-5
SILYBIN A
4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
SILYBININ
[2R-[2a,3b,6(2R*,3R*)]]-2-[2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
silliver
Silibinin
Silybin
Silybum Substance E6
silybine
MFCD00872186
7c3mt
Silymrin
Dura-Silymarin
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
793.0±60.0 °C at 760 mmHg
[ Melting Point ]:
164-174°C
[ Molecular Formula ]:
C25H22O10
[ Molecular Weight ]:
482.436
[ Flash Point ]:
274.5±26.4 °C
[ Exact Mass ]:
482.121307
[ PSA ]:
155.14000
[ LogP ]:
2.59
[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C
[ Index of Refraction ]:
1.684
[ Storage condition ]:
−20°C
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DJ2981770
- CHEMICAL NAME :
- 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphen yl)-2- (hydroxymethyl)-1,4-benzodioxin-6-yl)-3,5,7-trihydrox y-, (2R-(2-alpha,3-beta,6(2R*,3R*)))-
- CAS REGISTRY NUMBER :
- 22888-70-6
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C25-H22-O10
- MOLECULAR WEIGHT :
- 482.47
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1056 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,404,1983
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,404,1983
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39-S24/25-S22
[ RIDADR ]:
3172
[ WGK Germany ]:
3
[ RTECS ]:
DJ2981770
[ HS Code ]:
2932999099
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Chromatogr. A. 1394 , 137-47, (2015)
Extraction parameters, chemical fingerprint, and the single compounds' activity levels were considered for the selection of active botanicals. For an initial survey, the total bioactivity (i.e., total...
The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.J. Pharm. Pharmacol. 66(9) , 1339-46, (2014)
The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates 7-methoxy-4-...
Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits.Eur. J. Drug Metab. Pharmacokinet. 39(4) , 277-81, (2014)
Silibinin, a major constituent of silymarin, is widely used for its hepatoprotective effects. This study investigated the effect of silibinin on the pharmacokinetics of oral nitrendipine in rabbits. I...