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Senkyunolide I

Names

[ CAS No. ]:
94596-28-8

[ Name ]:
Senkyunolide I

[Synonym ]:
seneciphyllin
1(3H)-Isobenzofuranone, 3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6S,7S)-
SenkyunolideI
(3Z,6S,7S)-3-Butylidene-6,7-dihydroxy-4,5,6,7-tetrahydro-2-benzofuran-1(3H)-one
UNII:12PJ07292V

Biological Activity

[Description]:

Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Inflammation/Immunology

[References]

[1]. Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63(2):261-6.

[2]. Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
444.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H16O4

[ Molecular Weight ]:
224.253

[ Flash Point ]:
175.1±22.2 °C

[ Exact Mass ]:
224.104858

[ PSA ]:
66.76000

[ LogP ]:
1.04

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.571

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds