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Pectolinarin

Names

[ CAS No. ]:
28978-02-1

[ Name ]:
Pectolinarin

[Synonym ]:
5-Hydroxy-6-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
5-hydroxy-6-methoxy-2-(4-methoxyphenyl)
5-Hydroxy-6-methoxy-2-(4-methoxyphenyl)-7-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
neolinarin
Pectolinaroside
4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-
Pectolinarigenin 7-Rutinoside
PECTOLINARIN(P)
7-((6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Pectolinarin
4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-
pectolinarigenin 7-O-rutinoside

Biological Activity

[Description]:

Pectolinarin, isolated from Cirsium chanroenicum, possesses anti-inflammatory activity[1]. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[Target]

IL-6

IL-8

PGE2

NO

Apoptosis


[In Vitro]

Pectolinarin increases Bax level, and decreases Bcl-2 level in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Pectolinarin inactivates the PI3K/Akt pathway in RA-FLSs[2].

[References]

[1]. Lim H, et al. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull. 2008 Nov;31(11):2063-7.

[2]. Wang L, et al. Pectolinarin inhibits proliferation, induces apoptosis, and suppresses inflammation in rheumatoid arthritis fibroblast-like synoviocytes by inactivating the phosphatidylinositol 3 kinase/protein kinase B pathway.J Cell Biochem. 2019 Sep;120(9):15202-15210.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
896.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H34O15

[ Molecular Weight ]:
622.571

[ Flash Point ]:
292.4±27.8 °C

[ Exact Mass ]:
622.189758

[ PSA ]:
227.20000

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.683

[ Storage condition ]:
2~8℃

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29389090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds