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6-Hydroxyrubiadin

Names

[ CAS No. ]:
87686-86-0

[ Name ]:
6-Hydroxyrubiadin

[Synonym ]:
1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone
1,3,6-trihydroxy-2-methylanthracene-9,10-dione
9,10-Anthracenedione, 1,3,6-trihydroxy-2-methyl-
2-Methyl-1,3,6-trihydroxyanthraquinone

Biological Activity

[Description]:

6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

6-hydroxyrubiadin suppresses lipopolysaccharide (LPS)-induced nuclear factor-kappa B activation as well as the phosphorylation of c-Jun N-terminal kinase in RAW 264.7 macrophages[1]. 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-a, interleukin (IL)-1b and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7cells[1].

[In Vivo]

6-hydroxyrubiadin can reduce the production of pro-inflammatory cytokines and ameliorate acute lung injury (ALI) in a mouse model[1].

[References]

[1]. Yanting Wu, et al. In vitro and in vivo inhibitory effects of 6-hydroxyrubiadin on lipopolysaccharide-induced inflammation. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):107-116.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
558.7±19.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H10O5

[ Molecular Weight ]:
270.237

[ Flash Point ]:
305.7±18.0 °C

[ Exact Mass ]:
270.052826

[ PSA ]:
94.83000

[ LogP ]:
4.42

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.745

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds