Ethylenediaminetetraacetic acid

Names

[ CAS No. ]:
60-00-4

[ Name ]:
Ethylenediaminetetraacetic acid

[Synonym ]:
EINECS 200-449-4
EDTA
2,2',2'',2'''-(1,2-Ethanediyldinitrilo)tetraacetic acid
Ethylenediaminetetraacetic acid
Ethylene diamine tetraacetic acid
edetic acid
ethylenediamine-N,N,N',N'-tetraacetic acid
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-
2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid
Ethylenediamine tetraacetic acid
4-04-00-02449 (Beilstein Handbook Reference)
Versene acid
N,N'-1,2-Ethanediylbis[N-(carboxymethyl)glycine]
MFCD00003541

Biological Activity

[Description]:

Ethylenediaminetetraacetic acid is the acid form of Edetate, a chelating agent with anti-hypercalcemic and anticoagulant properties. Ethylenediaminetetraacetic acid binds calcium and heavy metal ions, forming soluble stable complexes. Ethylenediaminetetraacetic acidis also used as an anticoagulant for blood specimens and is applied as a treatment of lead poisoning[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Robert S Chumanov, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
614.2±55.0 °C at 760 mmHg

[ Melting Point ]:
250 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₁₆N₂O₈

[ Molecular Weight ]:
292.243

[ Flash Point ]:
325.2±31.5 °C

[ Exact Mass ]:
292.090668

[ PSA ]:
155.68000

[ LogP ]:
-0.43

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with copper, copper alloys, nickel, aluminium, strong oxidizing agents, strong bases

[ Water Solubility ]:
0.5 g/L (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH4025000

CHEMICAL NAME :: Acetic acid, (ethylenedinitrilo)tetra-

CAS REGISTRY NUMBER :: 60-00-4

BEILSTEIN REFERENCE NO. :: 1716295

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C10-H16-N2-O8

MOLECULAR WEIGHT :: 292.28

WISWESSER LINE NOTATION :: QV1N1VQ2N1VQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 397 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7632 mg/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7632 mg/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7632 mg/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3 gm/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rabbit Kidney

DOSE/DURATION :: 250 umol/L

REFERENCE :: ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 36,92,1964 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80283 No. of Facilities: 12157 (estimated) No. of Industries: 122 No. of Occupations: 93 No. of Employees: 121906 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80283 No. of Facilities: 14680 (estimated) No. of Industries: 119 No. of Occupations: 116 No. of Employees: 509055 (estimated) No. of Female Employees: 315637 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S61-S37/39-S36

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
AH4025000

[ HS Code ]:
2921219000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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