N-Methyltyramine

Names

[ CAS No. ]:
370-98-9

[ Name ]:
N-Methyltyramine

[Synonym ]:
N-Methyltyramine
4-Hydroxy-N-methylphenethylamine
Methyl-4-tyramine
Phenol, p-[2-(methylamino)ethyl]-
Phenol, 4-[2-(methylamino)ethyl]-
4-[2-(Methylamino)ethyl]phenol
N-methyl-p-Tyramine
WIN 5582
Tyramine,N-methyl
tyramine, N-methyl-
4-(2-Methylamino-ethyl)-phenol

Biological Activity

[Description]:

N-Methyltyramine is a protoalkaloid that can be isolated from various plant species. N-Methyltyramine is an α2-adrenoreceptor antagonist. N-Methyltyramine enhances appetite and digestion of foods by stimulating gastrin and pancreatic secretions. N-Methyltyramine can relax mouse small intestinal smooth muscle and inhibits small intestinal propulsion[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Metabolic Disease

[References]

[1]. Stohs SJ, et al. A review of the receptor binding and pharmacological effects of N-methyltyramine. Phytother Res. 2015 Jan;29(1):14-6.

[2]. Ni J, et al. Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders. Biomed Pharmacother. 2019 Mar;111:1393-1398.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
270.9±15.0 °C at 760 mmHg

[ Melting Point ]:
121 - 126°C(lit.)

[ Molecular Formula ]:
C₉H₁₃NO

[ Molecular Weight ]:
151.21

[ Flash Point ]:
119.7±11.0 °C

[ Exact Mass ]:
151.099716

[ PSA ]:
32.26000

[ LogP ]:
0.86

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL8300000

CHEMICAL NAME :: Phenol, p-(2-methylaminoethyl)-

CAS REGISTRY NUMBER :: 370-98-9

BEILSTEIN REFERENCE NO. :: 2357129

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H13-N-O

MOLECULAR WEIGHT :: 151.23

WISWESSER LINE NOTATION :: QR D2M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952

Safety Information

[ Hazard Codes ]:
C

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%