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ML355

Names

[ CAS No. ]:
1532593-30-8

[ Name ]:
ML355

[Synonym ]:
ML355
N-(1,3-Benzothiazol-2-yl)-4-[(2-hydroxy-3-methoxybenzyl)amino]benzenesulfonamide
Benzenesulfonamide, N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-

Biological Activity

[Description]:

ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.IC50 value: 0.34 μM [1]Target: 12-LOXML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Research Areas >> Inflammation/Immunology

[References]

[1]. Luci DK, et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506.

[2]. Zhang XJ, et al. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. Nat Med. 2018 Jan;24(1):73-83.


[Related Small Molecules]

U73122 | Zileuton | Nordihydroguaiaretic acid | Indirubin-3'-monoxime | Caffeic acid | marmesin | Malotilate | 4',5-Dihydroxyflavone | Enazadrem | LY 178002 | RWJ 63556 | S-2474 | 5-Lipoxygenase-In-1 | A-69412 | AZD 4407

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
654.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H19N3O4S2

[ Molecular Weight ]:
441.523

[ Flash Point ]:
349.6±34.3 °C

[ Exact Mass ]:
441.081696

[ LogP ]:
3.95

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.725

[ Storage condition ]:
2-8℃

Related Compounds