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Momordin Ic

Names

[ CAS No. ]:
96990-18-0

[ Name ]:
Momordin Ic

[Synonym ]:
(3β)-28-Hydroxy-28-oxoolean-12-en-3-yl 3-O-β-D-xylopyranosyl-β-D-glucopyranosiduronic acid
oleanolic acid 3-O-monodesmoside
MomordinIc
X1188
Olean-12-en-28-oic acid, 3-[(3-O-β-D-xylopyranosyl-β-D-glucopyranuronosyl)oxy]-, (3β)-
Scoparianoside B
Momordin Ic

Biological Activity

[Description]:

Momordin Ic is a principal saponin constituent of Fructus Kochiae, with with anti-cancer bioactivity. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Mi Y, et al. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016 Jan;90:230-42.

[2]. Wang J, et al. Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways. Toxicol In Vitro. 2019 Apr;56:75-83.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
886.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C41H64O13

[ Molecular Weight ]:
764.939

[ Flash Point ]:
263.1±27.8 °C

[ Exact Mass ]:
764.434692

[ PSA ]:
212.67000

[ LogP ]:
9.87

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.606

Safety Information

[ Safety Phrases ]:
24/25

Precursor & DownStream

Precursor

DownStream

Related Compounds