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CGP 36216

Names

[ CAS No. ]:
123691-29-2

[ Name ]:
CGP 36216

Biological Activity

[Description]:

CGP36216 (Compound 9) is a GABAB receptor antagonist. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 can be used for research of anxiety and trauma-related disorders[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

GABAB receptor[1]


[References]

[1]. William Howson, et al. Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity. Bioorganic & Medicinal Chemistry Letters. Volume 3, Issue 4, April 1993, Pages 515-518.

[2]. Adkins JM, et al. Presynaptic GABAB receptor inhibition sex dependently enhances fear extinction and attenuates fear renewal. Psychopharmacology (Berl). 2021 Aug;238(8):2059-2071.  

Chemical & Physical Properties

[ Molecular Formula ]:
C5H14NO2P

[ Molecular Weight ]:
151.14

[ Exact Mass ]:
187.05300

[ PSA ]:
73.13000

[ LogP ]:
2.12780

Related Compounds