U-46619
Names
[ CAS No. ]:
56985-40-1
[ Name ]:
U-46619
[Synonym ]:
5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5Z)-
(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}-5-heptenoic acid
MFCD00135238
U 46619,(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoicacid
Biological Activity
[Description]:
[Related Catalog]:
[Target]
TXA2[1]
[In Vitro]
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
519.7±30.0 °C at 760 mmHg
[ Molecular Formula ]:
C21H34O4
[ Molecular Weight ]:
350.492
[ Flash Point ]:
176.1±18.1 °C
[ Exact Mass ]:
350.245697
[ PSA ]:
66.76000
[ LogP ]:
3.90
[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C
[ Index of Refraction ]:
1.548
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MJ9681090
- CHEMICAL NAME :
- 5-Heptenoic acid, 7-(6-(3-hydroxy-1-octenyl)-2-oxabicyclo(2.2.1)hept-5- yl)-, (1R-(1-alpha, 4-alpha,5-beta(Z),6-alpha(1E,3S*)))-
- CAS REGISTRY NUMBER :
- 56985-40-1
- LAST UPDATED :
- 198306
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H34-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 66 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 224,369,1983
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H319-H336
[ Supplemental HS ]:
Repeated exposure may cause skin dryness or cracking.
[ Precautionary Statements ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F;Xi
[ Risk Phrases ]:
R11;R36;R66;R67
[ Safety Phrases ]:
S16;S26
[ RIDADR ]:
UN 1231 3/PG 2
Articles
Thromb. Haemost. 112(1) , 142-50, (2014)
ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influen...
Thromboxane A(2) receptor stimulation promotes closure of the rat ductus arteriosus through enhancing neointima formation.PLoS ONE 9(4) , e94895, (2014)
Ductus arteriosus (DA) closure follows constriction and remodeling of the entire vessel wall. Patent ductus arteriosus occurs when the DA does not close after birth, and this condition is currently tr...
A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel.Platelets 25(8) , 612-8, (2014)
There is wide variation in response to antiplatelet therapy and high on-treatment platelet reactivity is associated with adverse cardiovascular events. The objective here was to determine whether the ...