Windorphen

Names

[ CAS No. ]:
19881-70-0

[ Name ]:
Windorphen

[Synonym ]:
(Z)-3-chloro-2,3-bis(4-methoxyphenyl)propenal
3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE

Biological Activity

[Description]:

Windorphen is a Wnt/β-catenin signal inhibitor that specifically targets the function of the c-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Wnt

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[References]

[1]. Jijun Hao, et al. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep. 2013 Sep 12;4(5):898-904.

Chemical & Physical Properties

[ Density]:
1.198g/cm3

[ Boiling Point ]:
468.1ºC at 760mmHg

[ Melting Point ]:
160-163ºC

[ Molecular Formula ]:
C₁₇H₁₅ClO₃

[ Molecular Weight ]:
302.75

[ Flash Point ]:
184.7ºC

[ Exact Mass ]:
302.07100

[ PSA ]:
35.53000

[ LogP ]:
4.00980

[ Vapour Pressure ]:
6.15E-09mmHg at 25°C

[ Index of Refraction ]:
1.579

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2913000090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2913000090

[ Summary ]:
HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%