BMY 14802 hydrochloride
Names
[ CAS No. ]:
105565-55-7
[ Name ]:
BMY 14802 hydrochloride
Biological Activity
[Description]:
BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3].
[Related Catalog]:
[Target]
5-HT1A Receptor
α1-adrenergic receptor
sigma Receptor:112 nM (IC50)
[In Vitro]
Similar to other 5-HT1A agonists, BMY-14802 hydrochloride affects the firing of 5-HTergic and catecholaminergic neurons and affects behaviors mediated by 5-HT in a 5-HT1A-sensitive manner. BMY-14802 hydrochloride is devoid of significant affinity for the D2 receptor[3].
[In Vivo]
BMY-14802 (5 mg/kg, 10 mg/kg or 20 mg/kg, ip; once) hydrochloride shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias (LID) and is also effective in reducing D1 and D2 receptor agonist-induced dyskinesias. Importantly, at anti-LID doses, BMY-14802 hydrochloride does not affect the efficacy of L-DOPA against lesion-induced akinesia[2].
[References]
Chemical & Physical Properties
[ Boiling Point ]:
520.8ºC at 760mmHg
[ Molecular Formula ]:
C18H23ClF2N4O
[ Molecular Weight ]:
384.85100
[ Flash Point ]:
268.8ºC
[ Exact Mass ]:
384.15300
[ PSA ]:
52.49000
[ LogP ]:
3.19550
[ Vapour Pressure ]:
1.13E-11mmHg at 25°C