7-Hydroxycoumarine

Names

[ CAS No. ]:
93-35-6

[ Name ]:
7-Hydroxycoumarine

[Synonym ]:
UMBELLIFERON
2H-1-Benzopyran-2-one, 7-hydroxy-
Hydrangine
Umbelliferone
Hydramgin
7-Hydroxy-2H-chromen-2-one
Dichrin A
7-hydroxy-2H-1-benzopyran-2-one
EINECS 202-240-3
Skimmetine
umberlliferone
SKIMMETIN
7-Hydroxycoumarin
7-hydroxy-coumarin
7-hydroxy-coumarine
MFCD01861511
hydrangin
7 HC

Biological Activity

[Description]:

Umbelliferone, a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.

[Related Catalog]:

Natural Products >> Phenylpropanoids

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Yu SM, et al. Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 2015 Sep;12(3):3869-3873.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
382.1±37.0 °C at 760 mmHg

[ Melting Point ]:
230 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₆O₃

[ Molecular Weight ]:
162.142

[ Flash Point ]:
181.2±19.3 °C

[ Exact Mass ]:
162.031693

[ PSA ]:
50.44000

[ LogP ]:
1.58

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.640

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
1 g/100 mL (100 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6820000

CHEMICAL NAME :: Coumarin, 7-hydroxy-

CAS REGISTRY NUMBER :: 93-35-6

BEILSTEIN REFERENCE NO. :: 0127683

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H6-O3

MOLECULAR WEIGHT :: 162.15

WISWESSER LINE NOTATION :: T66 BOVJ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Klebsiella pneumoniae

DOSE/DURATION :: 800 mg/L

REFERENCE :: JIMMBG Journal of Immunological Methods. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1971- Volume(issue)/page/year: 36,55,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GN6820000

[ HS Code ]:
29322980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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