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SIB 1508Y maleate

Names

[ CAS No. ]:
192231-16-6

[ Name ]:
SIB 1508Y maleate

[Synonym ]:
3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine (2Z)-2-butenedioate (1:1)
Pyridine, 3-methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]-, (2Z)-2-butenedioate (1:1)

Biological Activity

[Description]:

SIB-1508Y is an orally active and selective nAChR agonist. SIB-1508Y has the potential to study parkinsonism[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[References]

[1]. Cosford ND, et al. (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1996 Aug 16;39(17):3235-7.  

[2]. Schneider JS, et al. Effects of SIB-1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys. Mov Disord. 1998 Jul;13(4):637-42.  

Chemical & Physical Properties

[ Melting Point ]:
152.5-153.5 °C

[ Molecular Formula ]:
C16H18N2O4

[ Molecular Weight ]:
302.33

[ Exact Mass ]:
292.142303

Related Compounds