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AMPK activator D942

Names

[ CAS No. ]:
849727-81-7

[ Name ]:
AMPK activator D942

[Synonym ]:
AMPK Activator
5-(3-{4-[2-(4-Fluorophenyl)ethoxy]phenyl}propyl)-2-furoic acid
IN1531
2-Furancarboxylic acid,5-[3-[4-[2-(4-fluorophenyl)ethoxy]phenyl]propyl]
D942
2-Furancarboxylic acid, 5-[3-[4-[2-(4-fluorophenyl)ethoxy]phenyl]propyl]-
5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid

Biological Activity

[Description]:

D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[References]

[1]. Baumann P, et al. Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells. Exp Cell Res. 2007 Oct 1;313(16):3592-603.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
538.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H21FO4

[ Molecular Weight ]:
368.398

[ Flash Point ]:
279.5±30.1 °C

[ Exact Mass ]:
368.142395

[ PSA ]:
59.67000

[ LogP ]:
5.35

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds