Carcinine hydrochloride salt

Names

[ Name ]:
Carcinine hydrochloride salt

[Synonym ]:
Propanamide, 3-amino-N-[2-(1H-imidazol-5-yl)ethyl]-
carcinine
N-[2-(1H-Imidazol-5-yl)ethyl]-β-alaninamide
3-amino-N-[2-(1H-imidazol-5-yl)ethyl]propanamide

Biological Activity

[Description]:

Alistin (Carcinine; β-Alanylhistamine) is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Zhong Chen, et al. Pharmacological effects of carcinine on histaminergic neurons in the brain. Br J Pharmacol. 2004 Nov;143(5):573-80.

[2]. Lea D Marchette, et al. Carcinine has 4-hydroxynonenal scavenging property and neuroprotective effect in mouse retina. Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3572-83.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
547.6±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₄N₄O

[ Molecular Weight ]:
182.22

[ Flash Point ]:
285.0±27.3 °C

[ Exact Mass ]:
182.116760

[ PSA ]:
87.29000

[ LogP ]:
-1.83

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.559

[ Storage condition ]:
20°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2933290090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%