Catharanthine
Names
[ CAS No. ]:
2468-21-5
[ Name ]:
Catharanthine
[Synonym ]:
Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2α,5β,18β)-
Methyl (2α,5β,18β)-3,4-didehydroibogamine-18-carboxylate
Catharanthine Sulphate
catharintine
CatharanthineSulfateBase
catharantine
(2α,5β,6α,18β)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester
Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2a,5b,6a,18b)-
(+)-3,4-Didehydrocoronaridine
Catharanthine
catharanthin
UNII-WT0YJV846J
catharinthine
MFCD01753356
Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2α,5β,6α,18β)-
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
491.5±45.0 °C at 760 mmHg
[ Melting Point ]:
138-140ºC
[ Molecular Formula ]:
C21H24N2O2
[ Molecular Weight ]:
336.427
[ Flash Point ]:
251.1±28.7 °C
[ Exact Mass ]:
336.183777
[ PSA ]:
45.33000
[ LogP ]:
4.05
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.663
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NH6732500
- CHEMICAL NAME :
- Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2-alpha,5-beta,6-alpha,18-beta)-
- CAS REGISTRY NUMBER :
- 2468-21-5
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H24-N2-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 26,1213,1977
Safety Information
[ Hazard Codes ]:
Xn
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Pharmacol. Exp. Ther. 345(3) , 383-92, (2013)
Catharanthine is a constituent of anticancer vinca alkaloids. Its cardiovascular effects have not been investigated. This study compares the in vivo hemodynamic as well as in vitro effects of catharan...
The leaf epidermome of Catharanthus roseus reveals its biochemical specialization.Plant Cell 20(3) , 524-42, (2008)
Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and...
Simultaneous determination of vinblastine and its monomeric precursors vindoline and catharanthine in Catharanthus roseus by capillary electrophoresis-mass spectrometry.J. Sep. Sci. 34 , 2885-2892, (2011)
Catharanthus roseus is an important dicotyledonous medicinal plant that contains various anticancer components, such as vinblastine (VLB) and its monomeric precursors (vindoline and catharanthine). A ...