4-thiouridine

Names

[ Name ]:
4-thiouridine

[Synonym ]:
EINECS 237-735-3
2(1H)-Pyrimidinone, 3,4-dihydro-1-β-D-ribofuranosyl-4-thioxo-
4-Thio-uridin
4-Thio-D-uridine
MFCD00006538
4-thio-uridine
1-(β-D-Ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
Uridine,4-thio
thiouridine
4-SH-Ur
THIOURIDINE,4
4-thiouridine

Biological Activity

[Description]:

4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

4-thiouridine (0-10 μM) labels and purifies nascent rRNA without significantly affecting rRNA synthesis[1]. 4-thiouridine (≥50 μM) strongly inhibits production and processing of rRNA[1].

[References]

[1]. Burger K, et al. 4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol. 2013 Oct;10(10):1623-30.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Melting Point ]:
139-140℃ (ethanol )

[ Molecular Formula ]:
C₉H₁₂N₂O₅S

[ Molecular Weight ]:
260.267

[ Exact Mass ]:
260.046692

[ PSA ]:
139.80000

[ LogP ]:
-0.21

[ Index of Refraction ]:
1.733

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
C

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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