<Suppliers Price>

1-[(2S)-2-Aminopropyl]-1H-indazol-6-ol

Names

[ CAS No. ]:
210580-75-9

[ Name ]:
1-[(2S)-2-Aminopropyl]-1H-indazol-6-ol

[Synonym ]:
1-[(2S)-2-Aminopropyl]-1H-indazol-6-ol
1-((S)-2-Amino-propyl)-1H-indazol-6; -ol
1-((S)-2-aminopropyl)-1H-indazol-6-ol
1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-

Biological Activity

[Description]:

AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

0.77 nM and 1.5 nM for rat and human 5-HT2 receptor[1]


[References]

[1]. Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13.  

[2]. Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174(19):3370-3381.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
372.8±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H13N3O

[ Molecular Weight ]:
191.23

[ Flash Point ]:
179.2±22.3 °C

[ Exact Mass ]:
191.105865

[ PSA ]:
63.81000

[ LogP ]:
0.81

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.652

Related Compounds