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AI-3

Names

[ CAS No. ]:
882288-28-0

[ Name ]:
AI-3

[Synonym ]:
L-368,899 hydrochloride

Biological Activity

[Description]:

AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

ARE[1]


[In Vitro]

AI-3 (0.1, 0.3, 1, 3.2, 10, 32 µM; 12, 24 h) 在 IMR-32 细胞中以剂量依赖方式增加 NQO1 的转录水平和蛋白质表达水平[1] . AI-3 (10 µM; 2-24 h) 诱导 GSH 合成从 4 小时开始到 24 小时[1]。 AI-3 在 IMR-32 细胞中的生物活性需要 Nrf2 和 PI3K的参与[1]。 Western Blot Analysis[1] Cell Line: IMR-32 cells Concentration: 0.1, 0.3, 1, 3.2, 10, 32 µM Incubation Time: 24 h Result: Induced NQO1 protein expression starting from 0.3 μM.

[References]

[1]. Wang R, et al. In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem Biol. 2013 Aug 16;8(8):1764-74.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H13ClO3S2

[ Molecular Weight ]:
292.80200

[ Exact Mass ]:
291.99900

[ PSA ]:
87.83000

[ LogP ]:
4.04090

Related Compounds