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Desmethyl-YM 298198

Names

[ CAS No. ]:
1177767-57-5

[ Name ]:
Desmethyl-YM 298198

[Synonym ]:
MFCD08458897
6-Amino-N-cyclohexyl-3-methyl[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride (1:1)
Thiazolo[3,2-a]benzimidazole-2-carboxamide, 6-amino-N-cyclohexyl-3-methyl-, hydrochloride (1:1)

Biological Activity

[Description]:

Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

16 nM (mGluR1)[1]


[References]

[1]. Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H21ClN4OS

[ Molecular Weight ]:
364.89

[ Exact Mass ]:
364.112457

Related Compounds